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KMID : 0351819860270040384
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Kyunpook University Medical Journal
1986 Volume.27 No. 4 p.384 ~ p.398
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Serum LDH Activities and LDH Isoenzyme Patterns in Various Diseases
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김인자
김재식 김중명
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Abstract
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The serum LDH activities and LDH isoenzyme patterns were determined in order to evaluate the clinical significances in various diseases presumed to be associated with LDH isoenzyme.
Totally 359 cases were investigated for the patients on the LDH isoenzyme test request.
In cardiovascular disorders, myocardial infarction showed high increase of LDH activity as 1023.0±132.73 U/L and LDH_1 isoenzyme increase was the main cause. Congestive heart failure showed moderate increase of LDH activity as 650.3±42.3 U/L and the increases of LDH_4 and LDH_5 were the cause.
In hepatobiliary disorders acute hepatitis showed moderate increase of LDH activity as 769.75±74.39 U/L and the cause was mainly LDH_5 increase. Chronic hepatitis, chronic liver disease and obstructive jaundice showed similar tendency and the same cause and the degrees were less prominent.
In hematologic disorders anema showed moderate increase of LDH activity as 746.7±155.65 U/L and leukemia showed high increase of LDH activity as 1119.3±126.69 U/L and these elevations were due to LDH_3, LDH_4 and LDH_5.
In respiratory disorders, pulmonary tuberculosis showed moderate increase of LDH activity as 740.0±117.63 U/L and this increase was due to LDH_4 and LDH_5.
CO intoxication, Reye's syndrome and asphyxia neonatorum showed very high increase of LDH activity up to 1619.0±516.05 U/L and the causes were LDH_1 and LDH_5, LDH_4 and LDH_5, and LDH_3, LDH_4 and LDH_5 respectively.
In diabetes mellitus a moderate increase of LDH activity was abserved as 675.2±44.98 U/L and it was from LDH_3, LDH_4 and LDH_5 increases.
In malignant tumors, LDH activity was increased as high as 962.0±248.50 U/L, and the cause was from LDH_3, LDH_4, and LDH_5 increases. And the most prominent increase was found in stomach Ca.
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KEYWORD
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LDH activities , LDH isoenzyme
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